Abstract
This study was carried out to determine the accumulations and alterations in some tissues of albino rats treated with lead metal and its eliminations using Cocus nucifera water. Forty-eight healthy albino rats of approximately 154g were distributed into 4 groups of 3 replicates with 4 rats each. 4g/kg bwt of lead nitrate dissolved in 1litre of distilled water were administered orally to rats in Group A. Group B takes 4g/kg bwt of lead salt and 15mg/kg bwt of C. nucifera water while Group C takes only 15mg/kg bwt of C. nucifera water twice weekly and Group D is the Healthy Control. The results show that the tissues concentration mean value of 0.23 ± 0.02 g/l (heart), 0.22 ± 0.04 g/l (kidney), 0.33 ± 0.02 g/l (liver) and 0.21 ± 0.04 g/l (lower gut) were recorded in the Groups A while there were significant reductions in these values when compared with the tissues concentration mean value of Group B (0.093 ± 0.01 g/l (heart), 0.011 ± 0.01 g/l (kidney), 0.065 ± 0.01g/l (liver) and 0.08 ± 0.01 g/l (low gut)). The tissue concentration mean values of 0 g/l were recorded in groups C and D respectively. Histopathological examination shows that alterations occur across all tissues of rats in Group A while tissues of the rats in Group B, C and D demonstrated normal architectural appearance. This study therefore suggest that C. nucifera water has the potency of eliminating lead metal and repairing altered tissues of albino rats.
Key Words: Ameliorations, Coconut water, Lead toxicity, Rattus norvegicus, Tissues
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